Bexarotene Good Manufacturer supply High Quality 153559-49-0
- Molecular Formula:C24H28O2
- Molecular Weight:348.485
- Appearance/Colour:white solid
- Melting Point:230-231 °C
- Boiling Point:489.7 °C at 760 mmHg
- PKA:4.08±0.10(Predicted)
- Flash Point:229.5 °C
- PSA：37.30000
- Density:1.042 g/cm3
- LogP:6.10370
Bexarotene (153559-49-0) Usage
Bexarotene is an agonist of retinoid X receptors (RXRs; EC50s = 28, 25, and 20 nM for RXRα, RXRβ, and RXRγ, respectively, in reporter assays). It is selective for RXRs over retinoic acid receptors (RARs; EC50s = >10 μM for RARα, RARβ, and RARγ). Bexarotene (10 μM) induces apoptosis in MJ, HuT 78, and HH cutaneous T cell lymphoma (CTCL) cells, as well as inhibits lung metastasis and angiogenesis in A549 and MDA-MB-231 mouse xenograft models when administered at a dose of 100 mg/kg per day. It reduces increased brain interstitial fluid levels of amyloid-β (1-40) (Aβ40) and Aβ42 in the APP/PS1 transgenic mouse model of Alzheimer’s disease. It also reduces viral load in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC90 = 9.4 μM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 = 2.01 μM). Formulations containing bexarotene have been used in the treatment of CTCL.
How to get the best price on Bexarotene?
Zibo Hangyu Biotechnology Development Co., Ltd is a quality supplier and manufacturer of Bexarotene . You can buy high quality, low price Bexarotene 153559-49-0 here.
Zibo Hangyu Biotechnology Development Co., Ltd. is a comprehensive chemical enterprise focusing on fine chemical products and pharmaceutical intermediates, integrating research and development, production and sales. The company is equipped with advanced equipment quality inspection and research center. At the same time, the company has excellent talents with rich experience in process development and quality control. To provide customers with total solutions from raw material processing to chemical synthesis systems. The company has established a standardized and perfect quality standard system to provide stable and high quality production and service.
Milestones
- 2012yearThe company was founded, began to engage in the production and supply of chemical raw materials
- 2014yearExpand the scale of production, pharmaceutical raw materials production workshop was established
- 2016yearCooperated with domestic and foreign chemical platforms to promote self-produced and high-end pharmaceutical intermediates
- 2019yearIn recent years to participate in the international pharmaceutical raw materials exhibitions
- 2023yearBusiness continues to expand, Production and Sales teams continue to grow
- 2026yearPlans to set up foreign branches
